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Last edited on 2011-07-07 12:52:27 by NiteshKhilwani [Reverting last edit by abxy94.neoplus.adsl.tpnet.pl [6734] to previous version [6729]]Additions:
====LiveSense: Cell-Based Sensing Microsystem====
@@{{image url="https://documents.epfl.ch/groups/n/na/nano-tera/www/liveSense.jpg " title="text" alt="text"}}@@
====About LiveSense====
====Conferences : ====
- **Prof Viola Vogel**: Laboratory for Biologically Oriented Materials - **“The Force-full Play of Cells”**
**12th Topical Seminar on Innovative Particle and Radiation Detectors (IPRD10)**, 7-10 June 2010, Siena, Italy
- **P. Renaud**'s poster **emphasizing the collaborative work with **[[CMOSAIC CMOSAIC]]**.
====What is LiveSense====
This project addresses the urgent need to improve the environmental monitoring of the many chemical and biological compounds that are affecting our biosphere and eventually human health. In this context, there is a lack of cost effective sensor networks capable of a reliable analysis of the complex mixtures of chemicals and biological agents present in low concentrations in our environment, watch the from the expert. None of the existing analytical chemistry or biosensing technologies available today meets the requirements for a large-scale deployment of autonomous sensor networks.
We propose to solve the problem by using living cells. Living cells are the most natural biosensors, since they integrate the biological effects of the compound mixtures and respond by metabolic or phenotypic changes that are relevant to potential effects in the human body. In living cell-based sensors, the cellular responses are measured in real time by secondary probes or sensors that can be optical, chemical or electrical microsensors. Whereas it is now firmly established that living cells are excellent for biosensing of toxic compounds the main scientific and technological challenge remaining is to control growth conditions and embed living cells within an autonomous microsystem for a long period of time. Furthermore, much work remains to be done to optimize the response detection by secondary sensing methods, and integrate all this into a microsystem.
The whole project is therefore centered around the realization of a complete autonomous microsystem that would include: (1) a cell culture microbioreactor, (2) a number of secondary sensors to measure cell response and monitor the microbioreactor process, (3) a signal processing control unit and (4) a wireless communication unit to link the microsystem to a sensor network.
We will base our research on known cell models selected in two cell types. First, bacteria will be used because there is already a wide experience on bacterial bioreporters and they are relatively easy to culture. The scientific challenges here will be in making a microbioreactor that allows continuous cell growth and a supply of active cells. Next challenge will be to design a reaction compartment to generate optimal response of the cells to the target analyte. Secondly, eukaryotic cells will be considered because their metabolic response to the toxicological reaction pathways in human and possibly more relevant to health-effect interpretations. Major scientific challenges in this part will be the loading and culturing of eukaryotic cells a lab-on-chip environment by using, for example, 3D gels supports to monitor their behaviour and finally to design appropriate probes and secondary sensors for real time monitoring of their response. Further technological and engineering challenges are to achieve the hybrid integration of living components into an autonomous microsystem and to interpret the secondary sensors signals into environmentally relevant information that can be sent through a sensor network.
====SEE ALSO: """"====
**[[http://www.nano-tera.ch/topdownbottomup/index.html Nano-Tera Top-Down Bottom-Up]]**
**[[HomePage NanoTeraWiki HomePage]]**
===Special Topics===
**[[Energy Energy]]**
**[[SensorNetwork Wireless Network Sensor]]**
**[[MicroFluidics Micro Fluidics]]**
**[[CarbonNanotube Carbon Nanotubes]]**
**[[GreenComputing Green Computing]]**
**[[BodyMonitoring Body Health Monitoring]]**
**[[Security Security]]**
----
[[CategoryWiki]]
{{nocomments}}
@@{{image url="https://documents.epfl.ch/groups/n/na/nano-tera/www/liveSense.jpg " title="text" alt="text"}}@@
====About LiveSense====
====Conferences : ====
- **Prof Viola Vogel**: Laboratory for Biologically Oriented Materials - **“The Force-full Play of Cells”**
**12th Topical Seminar on Innovative Particle and Radiation Detectors (IPRD10)**, 7-10 June 2010, Siena, Italy
- **P. Renaud**'s poster **emphasizing the collaborative work with **[[CMOSAIC CMOSAIC]]**.
====What is LiveSense====
This project addresses the urgent need to improve the environmental monitoring of the many chemical and biological compounds that are affecting our biosphere and eventually human health. In this context, there is a lack of cost effective sensor networks capable of a reliable analysis of the complex mixtures of chemicals and biological agents present in low concentrations in our environment, watch the from the expert. None of the existing analytical chemistry or biosensing technologies available today meets the requirements for a large-scale deployment of autonomous sensor networks.
We propose to solve the problem by using living cells. Living cells are the most natural biosensors, since they integrate the biological effects of the compound mixtures and respond by metabolic or phenotypic changes that are relevant to potential effects in the human body. In living cell-based sensors, the cellular responses are measured in real time by secondary probes or sensors that can be optical, chemical or electrical microsensors. Whereas it is now firmly established that living cells are excellent for biosensing of toxic compounds the main scientific and technological challenge remaining is to control growth conditions and embed living cells within an autonomous microsystem for a long period of time. Furthermore, much work remains to be done to optimize the response detection by secondary sensing methods, and integrate all this into a microsystem.
The whole project is therefore centered around the realization of a complete autonomous microsystem that would include: (1) a cell culture microbioreactor, (2) a number of secondary sensors to measure cell response and monitor the microbioreactor process, (3) a signal processing control unit and (4) a wireless communication unit to link the microsystem to a sensor network.
We will base our research on known cell models selected in two cell types. First, bacteria will be used because there is already a wide experience on bacterial bioreporters and they are relatively easy to culture. The scientific challenges here will be in making a microbioreactor that allows continuous cell growth and a supply of active cells. Next challenge will be to design a reaction compartment to generate optimal response of the cells to the target analyte. Secondly, eukaryotic cells will be considered because their metabolic response to the toxicological reaction pathways in human and possibly more relevant to health-effect interpretations. Major scientific challenges in this part will be the loading and culturing of eukaryotic cells a lab-on-chip environment by using, for example, 3D gels supports to monitor their behaviour and finally to design appropriate probes and secondary sensors for real time monitoring of their response. Further technological and engineering challenges are to achieve the hybrid integration of living components into an autonomous microsystem and to interpret the secondary sensors signals into environmentally relevant information that can be sent through a sensor network.
====SEE ALSO: """"====
**[[http://www.nano-tera.ch/topdownbottomup/index.html Nano-Tera Top-Down Bottom-Up]]**
**[[HomePage NanoTeraWiki HomePage]]**
===Special Topics===
**[[Energy Energy]]**
**[[SensorNetwork Wireless Network Sensor]]**
**[[MicroFluidics Micro Fluidics]]**
**[[CarbonNanotube Carbon Nanotubes]]**
**[[GreenComputing Green Computing]]**
**[[BodyMonitoring Body Health Monitoring]]**
**[[Security Security]]**
----
[[CategoryWiki]]
{{nocomments}}
Deletions:
[[http://fundiso.org/aulavirtual/user/view.php?id=1540&course=1 dffgfgffgfg]
[[http://www.oliveinet.com/user/view.php?id=1917&course=1 ddgfdsdsdsdgdfg]]
[[http://www.iescla.org/cursos/user/view.php?id=2450&course=1 dddsssaaadddddfg]]
[[http://ideab-ufps.com/plataforma/moodle/user/view.php?id=1586&course=1 dhhhhhhddfg]]
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**sdaaaaaaaaaaaaaaaa****sdaaaaaaaaaaaaaaaa****sdaaaaaaaaaaaaaaaa**
Revision [6734]
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++dsffffffffffffffffffff++++dsffffffffffffffffffff++ ++dsffffffffffffffffffff++
[[http://fundiso.org/aulavirtual/user/view.php?id=1540&course=1 dffgfgffgfg]
[[http://www.oliveinet.com/user/view.php?id=1917&course=1 ddgfdsdsdsdgdfg]]
[[http://www.iescla.org/cursos/user/view.php?id=2450&course=1 dddsssaaadddddfg]]
[[http://ideab-ufps.com/plataforma/moodle/user/view.php?id=1586&course=1 dhhhhhhddfg]]
++dsffffffffffffffffffff++++dsffffffffffffffffffff++
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[[http://fundiso.org/aulavirtual/user/view.php?id=1540&course=1 dffgfgffgfg]
[[http://www.oliveinet.com/user/view.php?id=1917&course=1 ddgfdsdsdsdgdfg]]
[[http://www.iescla.org/cursos/user/view.php?id=2450&course=1 dddsssaaadddddfg]]
[[http://ideab-ufps.com/plataforma/moodle/user/view.php?id=1586&course=1 dhhhhhhddfg]]
++dsffffffffffffffffffff++++dsffffffffffffffffffff++
**sdaaaaaaaaaaaaaaaa****sdaaaaaaaaaaaaaaaa****sdaaaaaaaaaaaaaaaa**
Deletions:
@@{{image url="https://documents.epfl.ch/groups/n/na/nano-tera/www/liveSense.jpg " title="text" alt="text"}}@@
====About LiveSense====
====Conferences : ====
- **Prof Viola Vogel**: Laboratory for Biologically Oriented Materials - **“The Force-full Play of Cells”**
**12th Topical Seminar on Innovative Particle and Radiation Detectors (IPRD10)**, 7-10 June 2010, Siena, Italy
- **P. Renaud**'s poster **emphasizing the collaborative work with **[[CMOSAIC CMOSAIC]]**.
====What is LiveSense====
This project addresses the urgent need to improve the environmental monitoring of the many chemical and biological compounds that are affecting our biosphere and eventually human health. In this context, there is a lack of cost effective sensor networks capable of a reliable analysis of the complex mixtures of chemicals and biological agents present in low concentrations in our environment, watch the from the expert. None of the existing analytical chemistry or biosensing technologies available today meets the requirements for a large-scale deployment of autonomous sensor networks.
We propose to solve the problem by using living cells. Living cells are the most natural biosensors, since they integrate the biological effects of the compound mixtures and respond by metabolic or phenotypic changes that are relevant to potential effects in the human body. In living cell-based sensors, the cellular responses are measured in real time by secondary probes or sensors that can be optical, chemical or electrical microsensors. Whereas it is now firmly established that living cells are excellent for biosensing of toxic compounds the main scientific and technological challenge remaining is to control growth conditions and embed living cells within an autonomous microsystem for a long period of time. Furthermore, much work remains to be done to optimize the response detection by secondary sensing methods, and integrate all this into a microsystem.
The whole project is therefore centered around the realization of a complete autonomous microsystem that would include: (1) a cell culture microbioreactor, (2) a number of secondary sensors to measure cell response and monitor the microbioreactor process, (3) a signal processing control unit and (4) a wireless communication unit to link the microsystem to a sensor network.
We will base our research on known cell models selected in two cell types. First, bacteria will be used because there is already a wide experience on bacterial bioreporters and they are relatively easy to culture. The scientific challenges here will be in making a microbioreactor that allows continuous cell growth and a supply of active cells. Next challenge will be to design a reaction compartment to generate optimal response of the cells to the target analyte. Secondly, eukaryotic cells will be considered because their metabolic response to the toxicological reaction pathways in human and possibly more relevant to health-effect interpretations. Major scientific challenges in this part will be the loading and culturing of eukaryotic cells a lab-on-chip environment by using, for example, 3D gels supports to monitor their behaviour and finally to design appropriate probes and secondary sensors for real time monitoring of their response. Further technological and engineering challenges are to achieve the hybrid integration of living components into an autonomous microsystem and to interpret the secondary sensors signals into environmentally relevant information that can be sent through a sensor network.
====SEE ALSO: """"====
**[[http://www.nano-tera.ch/topdownbottomup/index.html Nano-Tera Top-Down Bottom-Up]]**
**[[HomePage NanoTeraWiki HomePage]]**
===Special Topics===
**[[Energy Energy]]**
**[[SensorNetwork Wireless Network Sensor]]**
**[[MicroFluidics Micro Fluidics]]**
**[[CarbonNanotube Carbon Nanotubes]]**
**[[GreenComputing Green Computing]]**
**[[BodyMonitoring Body Health Monitoring]]**
**[[Security Security]]**
----
[[CategoryWiki]]
{{nocomments}}
Revision [6729]
Edited on 2011-07-07 12:07:31 by NiteshKhilwaniAdditions:
We will base our research on known cell models selected in two cell types. First, bacteria will be used because there is already a wide experience on bacterial bioreporters and they are relatively easy to culture. The scientific challenges here will be in making a microbioreactor that allows continuous cell growth and a supply of active cells. Next challenge will be to design a reaction compartment to generate optimal response of the cells to the target analyte. Secondly, eukaryotic cells will be considered because their metabolic response to the toxicological reaction pathways in human and possibly more relevant to health-effect interpretations. Major scientific challenges in this part will be the loading and culturing of eukaryotic cells a lab-on-chip environment by using, for example, 3D gels supports to monitor their behaviour and finally to design appropriate probes and secondary sensors for real time monitoring of their response. Further technological and engineering challenges are to achieve the hybrid integration of living components into an autonomous microsystem and to interpret the secondary sensors signals into environmentally relevant information that can be sent through a sensor network.
Deletions:
Revision [6718]
Edited on 2011-07-06 21:15:01 by abxy94.neoplus.adsl.tpnet.pl (unregistered user)Additions:
====LiveSense: Cell-Based Sensing Microsystem====
@@{{image url="https://documents.epfl.ch/groups/n/na/nano-tera/www/liveSense.jpg " title="text" alt="text"}}@@
====About LiveSense====
====Conferences : ====
- **Prof Viola Vogel**: Laboratory for Biologically Oriented Materials - **“The Force-full Play of Cells”**
**12th Topical Seminar on Innovative Particle and Radiation Detectors (IPRD10)**, 7-10 June 2010, Siena, Italy
- **P. Renaud**'s poster **emphasizing the collaborative work with **[[CMOSAIC CMOSAIC]]**.
====What is LiveSense====
This project addresses the urgent need to improve the environmental monitoring of the many chemical and biological compounds that are affecting our biosphere and eventually human health. In this context, there is a lack of cost effective sensor networks capable of a reliable analysis of the complex mixtures of chemicals and biological agents present in low concentrations in our environment, watch the from the expert. None of the existing analytical chemistry or biosensing technologies available today meets the requirements for a large-scale deployment of autonomous sensor networks.
We propose to solve the problem by using living cells. Living cells are the most natural biosensors, since they integrate the biological effects of the compound mixtures and respond by metabolic or phenotypic changes that are relevant to potential effects in the human body. In living cell-based sensors, the cellular responses are measured in real time by secondary probes or sensors that can be optical, chemical or electrical microsensors. Whereas it is now firmly established that living cells are excellent for biosensing of toxic compounds the main scientific and technological challenge remaining is to control growth conditions and embed living cells within an autonomous microsystem for a long period of time. Furthermore, much work remains to be done to optimize the response detection by secondary sensing methods, and integrate all this into a microsystem.
The whole project is therefore centered around the realization of a complete autonomous microsystem that would include: (1) a cell culture microbioreactor, (2) a number of secondary sensors to measure cell response and monitor the microbioreactor process, (3) a signal processing control unit and (4) a wireless communication unit to link the microsystem to a sensor network.
We will base our research on known cell models selected in two cell types. First, bacteria will be used because there is already a wide experience on bacterial bioreporters and they are relatively easy to culture. The scientific challenges here will be in making a microbioreactor that allows continuous cell growth and a supply of active cells. Next challenge will be to design a reaction compartment to generate optimal response of the cells to the target analyte. Secondly, eukaryotic cells will be considered because their metabolic response to the toxicological reaction pathways in human and possibly more relevant to health-effect interpretations. Major scientific challenges in this part will be the loading and culturing of eukaryotic cells a lab-on-chip environment by using, for example, 3D gels supports to monitor their behaviour and finally to design appropriate probes and secondary sensors for real time monitoring of their response. Further technological and engineering challenges are to achieve the hybrid integration of living components into an autonomous microsystem and to interpret the secondary sensors signals into environmentally relevant information that can be sent through a sensor network[[http://www.ferienhausnetz.eu/de/algarve.html .]]
====SEE ALSO: """"====
**[[http://www.nano-tera.ch/topdownbottomup/index.html Nano-Tera Top-Down Bottom-Up]]**
**[[HomePage NanoTeraWiki HomePage]]**
===Special Topics===
**[[Energy Energy]]**
**[[SensorNetwork Wireless Network Sensor]]**
**[[MicroFluidics Micro Fluidics]]**
**[[CarbonNanotube Carbon Nanotubes]]**
**[[GreenComputing Green Computing]]**
**[[BodyMonitoring Body Health Monitoring]]**
**[[Security Security]]**
----
[[CategoryWiki]]
{{nocomments}}
@@{{image url="https://documents.epfl.ch/groups/n/na/nano-tera/www/liveSense.jpg " title="text" alt="text"}}@@
====About LiveSense====
====Conferences : ====
- **Prof Viola Vogel**: Laboratory for Biologically Oriented Materials - **“The Force-full Play of Cells”**
**12th Topical Seminar on Innovative Particle and Radiation Detectors (IPRD10)**, 7-10 June 2010, Siena, Italy
- **P. Renaud**'s poster **emphasizing the collaborative work with **[[CMOSAIC CMOSAIC]]**.
====What is LiveSense====
This project addresses the urgent need to improve the environmental monitoring of the many chemical and biological compounds that are affecting our biosphere and eventually human health. In this context, there is a lack of cost effective sensor networks capable of a reliable analysis of the complex mixtures of chemicals and biological agents present in low concentrations in our environment, watch the from the expert. None of the existing analytical chemistry or biosensing technologies available today meets the requirements for a large-scale deployment of autonomous sensor networks.
We propose to solve the problem by using living cells. Living cells are the most natural biosensors, since they integrate the biological effects of the compound mixtures and respond by metabolic or phenotypic changes that are relevant to potential effects in the human body. In living cell-based sensors, the cellular responses are measured in real time by secondary probes or sensors that can be optical, chemical or electrical microsensors. Whereas it is now firmly established that living cells are excellent for biosensing of toxic compounds the main scientific and technological challenge remaining is to control growth conditions and embed living cells within an autonomous microsystem for a long period of time. Furthermore, much work remains to be done to optimize the response detection by secondary sensing methods, and integrate all this into a microsystem.
The whole project is therefore centered around the realization of a complete autonomous microsystem that would include: (1) a cell culture microbioreactor, (2) a number of secondary sensors to measure cell response and monitor the microbioreactor process, (3) a signal processing control unit and (4) a wireless communication unit to link the microsystem to a sensor network.
We will base our research on known cell models selected in two cell types. First, bacteria will be used because there is already a wide experience on bacterial bioreporters and they are relatively easy to culture. The scientific challenges here will be in making a microbioreactor that allows continuous cell growth and a supply of active cells. Next challenge will be to design a reaction compartment to generate optimal response of the cells to the target analyte. Secondly, eukaryotic cells will be considered because their metabolic response to the toxicological reaction pathways in human and possibly more relevant to health-effect interpretations. Major scientific challenges in this part will be the loading and culturing of eukaryotic cells a lab-on-chip environment by using, for example, 3D gels supports to monitor their behaviour and finally to design appropriate probes and secondary sensors for real time monitoring of their response. Further technological and engineering challenges are to achieve the hybrid integration of living components into an autonomous microsystem and to interpret the secondary sensors signals into environmentally relevant information that can be sent through a sensor network[[http://www.ferienhausnetz.eu/de/algarve.html .]]
====SEE ALSO: """"====
**[[http://www.nano-tera.ch/topdownbottomup/index.html Nano-Tera Top-Down Bottom-Up]]**
**[[HomePage NanoTeraWiki HomePage]]**
===Special Topics===
**[[Energy Energy]]**
**[[SensorNetwork Wireless Network Sensor]]**
**[[MicroFluidics Micro Fluidics]]**
**[[CarbonNanotube Carbon Nanotubes]]**
**[[GreenComputing Green Computing]]**
**[[BodyMonitoring Body Health Monitoring]]**
**[[Security Security]]**
----
[[CategoryWiki]]
{{nocomments}}
Deletions:
[[http://www.mrsvowell.org/classroom/user/view.php?id=1997&course=1 dadfdfdfdfgdfg]]
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gfffgfffg **asdddddddddddddddddddddddddddddddd**
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gfffgfffg **asdddddddddddddddddddddddddddddddd**
Revision [6716]
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[[http://www.mrsvowell.org/classroom/user/view.php?id=1997&course=1 dadfdfdfdfgdfg]]
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[[http://members.condadodealhamaservices.com/pg/blog/wheremymoney38 dsdfsghgdfg]]
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Deletions:
@@{{image url="https://documents.epfl.ch/groups/n/na/nano-tera/www/liveSense.jpg " title="text" alt="text"}}@@
====About LiveSense====
====Conferences : ====
- **Prof Viola Vogel**: Laboratory for Biologically Oriented Materials - **“The Force-full Play of Cells”**
**12th Topical Seminar on Innovative Particle and Radiation Detectors (IPRD10)**, 7-10 June 2010, Siena, Italy
- **P. Renaud**'s poster **emphasizing the collaborative work with **[[CMOSAIC CMOSAIC]]**.
====What is LiveSense====
This project addresses the urgent need to improve the environmental monitoring of the many chemical and biological compounds that are affecting our biosphere and eventually human health. In this context, there is a lack of cost effective sensor networks capable of a reliable analysis of the complex mixtures of chemicals and biological agents present in low concentrations in our environment, watch the from the expert. None of the existing analytical chemistry or biosensing technologies available today meets the requirements for a large-scale deployment of autonomous sensor networks.
We propose to solve the problem by using living cells. Living cells are the most natural biosensors, since they integrate the biological effects of the compound mixtures and respond by metabolic or phenotypic changes that are relevant to potential effects in the human body. In living cell-based sensors, the cellular responses are measured in real time by secondary probes or sensors that can be optical, chemical or electrical microsensors. Whereas it is now firmly established that living cells are excellent for biosensing of toxic compounds the main scientific and technological challenge remaining is to control growth conditions and embed living cells within an autonomous microsystem for a long period of time. Furthermore, much work remains to be done to optimize the response detection by secondary sensing methods, and integrate all this into a microsystem.
The whole project is therefore centered around the realization of a complete autonomous microsystem that would include: (1) a cell culture microbioreactor, (2) a number of secondary sensors to measure cell response and monitor the microbioreactor process, (3) a signal processing control unit and (4) a wireless communication unit to link the microsystem to a sensor network.
We will base our research on known cell models selected in two cell types. First, bacteria will be used because there is already a wide experience on bacterial bioreporters and they are relatively easy to culture. The scientific challenges here will be in making a microbioreactor that allows continuous cell growth and a supply of active cells. Next challenge will be to design a reaction compartment to generate optimal response of the cells to the target analyte. Secondly, eukaryotic cells will be considered because their metabolic response to the toxicological reaction pathways in human and possibly more relevant to health-effect interpretations. Major scientific challenges in this part will be the loading and culturing of eukaryotic cells a lab-on-chip environment by using, for example, 3D gels supports to monitor their behaviour and finally to design appropriate probes and secondary sensors for real time monitoring of their response. Further technological and engineering challenges are to achieve the hybrid integration of living components into an autonomous microsystem and to interpret the secondary sensors signals into environmentally relevant information that can be sent through a sensor network[[http://www.ferienhausnetz.eu/de/algarve.html .]]
====SEE ALSO: """"====
**[[http://www.nano-tera.ch/topdownbottomup/index.html Nano-Tera Top-Down Bottom-Up]]**
**[[HomePage NanoTeraWiki HomePage]]**
===Special Topics===
**[[Energy Energy]]**
**[[SensorNetwork Wireless Network Sensor]]**
**[[MicroFluidics Micro Fluidics]]**
**[[CarbonNanotube Carbon Nanotubes]]**
**[[GreenComputing Green Computing]]**
**[[BodyMonitoring Body Health Monitoring]]**
**[[Security Security]]**
----
[[CategoryWiki]]
{{nocomments}}
Revision [6714]
Edited on 2011-07-06 19:19:28 by abxy94.neoplus.adsl.tpnet.pl (unregistered user)Additions:
====LiveSense: Cell-Based Sensing Microsystem====
@@{{image url="https://documents.epfl.ch/groups/n/na/nano-tera/www/liveSense.jpg " title="text" alt="text"}}@@
====About LiveSense====
====Conferences : ====
- **Prof Viola Vogel**: Laboratory for Biologically Oriented Materials - **“The Force-full Play of Cells”**
**12th Topical Seminar on Innovative Particle and Radiation Detectors (IPRD10)**, 7-10 June 2010, Siena, Italy
- **P. Renaud**'s poster **emphasizing the collaborative work with **[[CMOSAIC CMOSAIC]]**.
====What is LiveSense====
This project addresses the urgent need to improve the environmental monitoring of the many chemical and biological compounds that are affecting our biosphere and eventually human health. In this context, there is a lack of cost effective sensor networks capable of a reliable analysis of the complex mixtures of chemicals and biological agents present in low concentrations in our environment, watch the from the expert. None of the existing analytical chemistry or biosensing technologies available today meets the requirements for a large-scale deployment of autonomous sensor networks.
We propose to solve the problem by using living cells. Living cells are the most natural biosensors, since they integrate the biological effects of the compound mixtures and respond by metabolic or phenotypic changes that are relevant to potential effects in the human body. In living cell-based sensors, the cellular responses are measured in real time by secondary probes or sensors that can be optical, chemical or electrical microsensors. Whereas it is now firmly established that living cells are excellent for biosensing of toxic compounds the main scientific and technological challenge remaining is to control growth conditions and embed living cells within an autonomous microsystem for a long period of time. Furthermore, much work remains to be done to optimize the response detection by secondary sensing methods, and integrate all this into a microsystem.
The whole project is therefore centered around the realization of a complete autonomous microsystem that would include: (1) a cell culture microbioreactor, (2) a number of secondary sensors to measure cell response and monitor the microbioreactor process, (3) a signal processing control unit and (4) a wireless communication unit to link the microsystem to a sensor network.
We will base our research on known cell models selected in two cell types. First, bacteria will be used because there is already a wide experience on bacterial bioreporters and they are relatively easy to culture. The scientific challenges here will be in making a microbioreactor that allows continuous cell growth and a supply of active cells. Next challenge will be to design a reaction compartment to generate optimal response of the cells to the target analyte. Secondly, eukaryotic cells will be considered because their metabolic response to the toxicological reaction pathways in human and possibly more relevant to health-effect interpretations. Major scientific challenges in this part will be the loading and culturing of eukaryotic cells a lab-on-chip environment by using, for example, 3D gels supports to monitor their behaviour and finally to design appropriate probes and secondary sensors for real time monitoring of their response. Further technological and engineering challenges are to achieve the hybrid integration of living components into an autonomous microsystem and to interpret the secondary sensors signals into environmentally relevant information that can be sent through a sensor network[[http://www.ferienhausnetz.eu/de/algarve.html .]]
====SEE ALSO: """"====
**[[http://www.nano-tera.ch/topdownbottomup/index.html Nano-Tera Top-Down Bottom-Up]]**
**[[HomePage NanoTeraWiki HomePage]]**
===Special Topics===
**[[Energy Energy]]**
**[[SensorNetwork Wireless Network Sensor]]**
**[[MicroFluidics Micro Fluidics]]**
**[[CarbonNanotube Carbon Nanotubes]]**
**[[GreenComputing Green Computing]]**
**[[BodyMonitoring Body Health Monitoring]]**
**[[Security Security]]**
----
[[CategoryWiki]]
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====About LiveSense====
====Conferences : ====
- **Prof Viola Vogel**: Laboratory for Biologically Oriented Materials - **“The Force-full Play of Cells”**
**12th Topical Seminar on Innovative Particle and Radiation Detectors (IPRD10)**, 7-10 June 2010, Siena, Italy
- **P. Renaud**'s poster **emphasizing the collaborative work with **[[CMOSAIC CMOSAIC]]**.
====What is LiveSense====
This project addresses the urgent need to improve the environmental monitoring of the many chemical and biological compounds that are affecting our biosphere and eventually human health. In this context, there is a lack of cost effective sensor networks capable of a reliable analysis of the complex mixtures of chemicals and biological agents present in low concentrations in our environment, watch the from the expert. None of the existing analytical chemistry or biosensing technologies available today meets the requirements for a large-scale deployment of autonomous sensor networks.
We propose to solve the problem by using living cells. Living cells are the most natural biosensors, since they integrate the biological effects of the compound mixtures and respond by metabolic or phenotypic changes that are relevant to potential effects in the human body. In living cell-based sensors, the cellular responses are measured in real time by secondary probes or sensors that can be optical, chemical or electrical microsensors. Whereas it is now firmly established that living cells are excellent for biosensing of toxic compounds the main scientific and technological challenge remaining is to control growth conditions and embed living cells within an autonomous microsystem for a long period of time. Furthermore, much work remains to be done to optimize the response detection by secondary sensing methods, and integrate all this into a microsystem.
The whole project is therefore centered around the realization of a complete autonomous microsystem that would include: (1) a cell culture microbioreactor, (2) a number of secondary sensors to measure cell response and monitor the microbioreactor process, (3) a signal processing control unit and (4) a wireless communication unit to link the microsystem to a sensor network.
We will base our research on known cell models selected in two cell types. First, bacteria will be used because there is already a wide experience on bacterial bioreporters and they are relatively easy to culture. The scientific challenges here will be in making a microbioreactor that allows continuous cell growth and a supply of active cells. Next challenge will be to design a reaction compartment to generate optimal response of the cells to the target analyte. Secondly, eukaryotic cells will be considered because their metabolic response to the toxicological reaction pathways in human and possibly more relevant to health-effect interpretations. Major scientific challenges in this part will be the loading and culturing of eukaryotic cells a lab-on-chip environment by using, for example, 3D gels supports to monitor their behaviour and finally to design appropriate probes and secondary sensors for real time monitoring of their response. Further technological and engineering challenges are to achieve the hybrid integration of living components into an autonomous microsystem and to interpret the secondary sensors signals into environmentally relevant information that can be sent through a sensor network[[http://www.ferienhausnetz.eu/de/algarve.html .]]
====SEE ALSO: """"====
**[[http://www.nano-tera.ch/topdownbottomup/index.html Nano-Tera Top-Down Bottom-Up]]**
**[[HomePage NanoTeraWiki HomePage]]**
===Special Topics===
**[[Energy Energy]]**
**[[SensorNetwork Wireless Network Sensor]]**
**[[MicroFluidics Micro Fluidics]]**
**[[CarbonNanotube Carbon Nanotubes]]**
**[[GreenComputing Green Computing]]**
**[[BodyMonitoring Body Health Monitoring]]**
**[[Security Security]]**
----
[[CategoryWiki]]
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