EPFL/STI/IMX/LTP
Expert in powder technology, surface, coatings and particle engineering
Heinrich Hofmann
EPFL
MagnetoTheranostics
From superparamagnetic nano-particles to tools for the detection and treatment of cancer
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UniGE/SSP/Biopharmacie
Expert in traitement de meétastases osseuses par chimiothérapie et thermothérapie combinées, microencapsulation d
Olivier Jordan
UniGE
ETHZ/ITIS
Expert in the development of measurement technologies, computational physics, in silico tissue models, physiological human models
Niels Kuster
ETHZ
CHUV/CIBM/CVMR
Expert in magnetic resonance in medicine
Matthias Stuber
CHUV
InselSpital
Expert in diagnostic, interventional pediatric radiology
Harriet Thöny
InselSpital
UZH/Equine Hospital
Expert in bone and cartilage research focusing on mechanisms of cartilage remodeling and resurfacing and substitutes for cartilage and bone
Brigitte von Rechenberg
UZH

Project Description

The use of superparamagnetic iron oxide nanoparticles as contrast agents is well known, additionally, such particles are used in as source for local heating of cancer (Hyperthermia, clinical tests). In these two applications, dextran coated nanoparticles are used; for example in imaging of the liver a passive accumulation of the particles occurs, whereas for hyperthermia the particles are injected directly into the tumor. Our work with such particles as well as that presented in the literature shows that the potential of superparamagnetic nanoparticles for medical application is much larger. Specific adsorption of the particles at tumor cells, organs or even as shown by EPFL at organelles inside cells, opens a very large field of diagnostic applications, especially as contrast agent for molecular imaging by MRI. Interestingly, particles used as contrast agent are also useful for hyperthermia applications because superparamagnetic nanoparticles have relaxation times which allow heating by applying alternating magnetic fields with field strengths and frequencies applicable to human bodies.   

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Our researchers in the media

Outstanding Laboratory Investigation for 2014

Novartis soutien le lancement du coffret d'expérimentation Nano en Suisse romande

Development of novel nanotechnology based diagnostic systems for early detection of Rheumatoid Arthritis and Osteoarthritis

Tackling tumors with iron oxide

Notable publications

Differentiation of Prostate Cancer Lesions With High and With Low Gleason Score by Diffusion-Weighted MRI.
Barbieri S, Brönnimann M, Boxler S, Thoeny HC
Eur Radiology, DOI 10.1007/s00330-016-4449-5

Impact of the calculation algorithm on biexponential fitting of diffusion-weighted MRI in upper abdominal organs.
Barbieri S, Donati OF, Froehlich JM, Thoeny HC.
Magn Reson Med. .Volume: 75 Issue: 5 Pages: 2175-2184 2016, doi: 10.1002/mrm.25765. 2015 Jun 8

Comparison of Intravoxel Incoherent Motion Parameters across MR Imagers and Field Strengths: Evaluation in Upper Abdominal Organs.
Sebastiano Barbieri, Olivio F. Donati, Johannes M. Froehlich, Harriet C. Thoeny
Radiology, 279 Issue: 3 , 784-794, 2016

Diffusion-weighted imaging outside the brain: Consensus statement from an ISMRM-sponsored workshop.
Taouli B, Beer AJ, Chenevert T, Collins D, Lehman C, Matos C, Padhani AR, Rosenkrantz AB, Shukla-Dave A, Sigmund E, Tanenbaum L, Thoeny H, Thomassin-Naggara I, Barbieri S, Corcuera-Solano I, Orton M, Partridge SC, Koh DM.
Radiology. 2015 Dec 16:151244.


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Posters from 2016


Iron oxide nanoparticles with superior properties for theranostics
Débora Bonvin, Jessica Bastiaansen, Matthias Stuber, Marijana Mionic Ebersold, Heinrich Hofmann

From superparamagnetic nanoparticles to cancer detection and treatment
Henning Richter, Harriet Thoeny, Matthias Stuber, Olivier Jordan, Nils Kuster, Brigitte von Rechenberg, Patrick Kircher, Heinrich Hofmann

Small and biocompatible coatings for lymph node metastases detection and treatment
Débora Bonvin, Duncan T.L. Alexander, Marijana Ebershold Mionic, Heinrich Hofmann

Targeted Nanoparticles for Imaging and Treatment of Prostate Cancer Metastases in Lymph Nodes
Stella-Saphira Ehrenberger, Emmanuelle Sublet, Gerrit Borchard, Olivier Jordan

Posters from 2015


From superparamagnetic nanoparticles to cancer detection and treatment
Henning Richter, Brigitte von Rechenberg, Patrick Kircher, Heinrich Hofmann

Characterization of iron oxide nanoparticles for theranostic applications
Débora Bonvin, Marijana Mionic, Jessica Bastiaansen, Angel Millan, Matthias Stuber, Heinrich Hofmann

In-Situ Forming Implant for Application of Local Hyperthermia in Cancer
Stella-Saphira Ehrenberger, Gerrit Borchard, Heinrich Hofmann, Olivier Jordan

Posters from 2014


From superparamagnetic nanoparticles to cancer detection and treatment
H. Richter, S. Barbieri, H. Thoeny, M. Stuber, O. Jordan, N. Kuster, B. von Rechenberg, P. Kircher, H. Hofmann

From superparamagnetic nanoparticles to cancer detection and treatment
Stella-Saphira Ehrenberger, Gerrit Borchard, Olivier Jordan

From superparamagnetic iron oxide nanoparticles until tools for detection and treatment of cancer
Débora Bonvin, Marijana Mionic, Heinrich Hofmann

Posters from 2013


From Cancer Detection to Treatment: MagnetoTheranostics
Marijana Mionic, Brigitte von Rechenberg, Harriet Thöny, Matthias Stuber, Olivier Jordan, Niels Kuster and Heinrich Hofmann

    

Project Photos